The RB1 gene is organized into 27 exons spanning
183 kb of genomic DNA (1). The RB1 gene is
ubiquitously expressed and transcribed into a
4.7 kb mRNA (2). The gene product (pRB protein)
has 928 amino acids (3). It is a 100 kD
phosphoprotein with important functions in
the regulation of the cell cycle. It is activated by
phosphorylation (P) during cell cycle progression
from G0 to G1 (p. 112) at about 12 distinct
serine and threonine residues. Three
functional domains, A, B, and C, and a nuclear
localization signal (NLS) can be distinguished.
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