A Philadelphia chromosome is present in the
bone marrow cells of most patients with the
chronic form of the disease (CML). If it is not
present, the illness progresses more rapidly
than usual and has a poorer prognosis. In addition,
the Philadelphia chromosome may be
found in some acute leukemias (acute lymphocytic
leukemia, ALL; acutemyelocytic leukemia,
AML) in adults and in children. Here, Ph1 indicates
a poor prognosis, whereas its absence is
favorable.
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