Fusion Gene as Cause of Tumors: CML

Chronicmyeloid leukemia (CML) is amalignant
tumor that originates from a single cell of the
bone marrow in adulthood. The number of myelocytes
(white blood cells from the bone marrow)
is greatly increased. The disease follows a
chronic course. Acute crises develop intermittently
and terminally. In about 90% of the
patients, affected bone marrow cells contain a
chromosome 22 with a shortened long arm
(22q–, Philadelphia chromosome).